A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib

Patel, T. V., Morgan, J. A., Demetri, G. D., George, S., Maki, R. G., Quigley, M., Humphreys, B. D. (February 2008) A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib. J Natl Cancer Inst, 100 (4). pp. 282-4. ISSN 1460-2105 (Electronic)0027-8874 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/18270341
DOI: 10.1093/jnci/djm311

Abstract

The oral multitargeted kinase inhibitors (MTKI) sunitinib (SU11248, Sutent; Pfizer, New York) and sorafenib (BAY 43-9006, Nexavar; Bayer Pharmaceuticals, West Haven, CT, and Onyx Pharmaceuticals, Emeryville, CA) are increasingly used to treat malignant solid tumors. These small-molecule agents inhibit signaling through receptor tyrosine kinases such as vascular endothelial growth factor (VEGF) receptor, platelet-derived growth factor receptor, and c-KIT, among others (1). In the kidney, glomerular podocytes express VEGF and glomerular endothelial cells express VEGF receptors. Podocyte-specific deletion of a single VEGF allele causes proteinuria and capillary endotheliosis in rodents, and disrupted glomerular VEGF signaling is strongly implicated in the pathogenesis of human preeclampsia (2–4).

Item Type: Paper
Uncontrolled Keywords: Antineoplastic Agents/*adverse effects Benzenesulfonates/*adverse effects Humans Hypertension/*chemically induced/metabolism Indoles/*adverse effects Niacinamide/analogs & derivatives Phenylurea Compounds Protein Kinase Inhibitors/*adverse effects Proteinuria/*chemically induced/metabolism Pyridines/*adverse effects Pyrroles/*adverse effects Receptors, Vascular Endothelial Growth Factor/*drug effects Signal Transduction/drug effects
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > drugs and therapies
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: 20 February 2008
Date Deposited: 26 Oct 2016 14:47
Last Modified: 26 Oct 2016 14:47
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33691

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