EBV-Associated Smooth Muscle Neoplasms: Solid Tumors Arising in the Presence of Immunosuppression and Autoimmune Diseases

Moore Dalal, K., Antonescu, C. R., Dematteo, R. P., Maki, R. G. (2008) EBV-Associated Smooth Muscle Neoplasms: Solid Tumors Arising in the Presence of Immunosuppression and Autoimmune Diseases. Sarcoma, 2008. p. 859407. ISSN 1357-714X (Print)1357-714X (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/19079588
DOI: 10.1155/2008/859407

Abstract

Background. Epstein-Barr virus (EBV)-related smooth muscle neoplasms (SMNs) have been associated with immune dysregulation, most notably in patients who have undergone solid organ transplantation or in patients with HIV/AIDS. Objective. to report our experience with EBV-related neoplasms as well as describing the first EBV-related SMN in the setting of administration of glucocorticoids and the tumor necrosis factor inhibitor etanercept. Design. We have case reports, of minimum 3-year follow-up, 2002-2005. Setting. It was held in an academic and tertiary referral cancer center. Patients. Patients are with dysregulated immunity after solid organ transplantation, HIV/AIDS, or with psoriasis after treatment with etanercept. Interventions. There were discontinuation of etanercept, right hepatic trisegmentectomy, and chemotherapy. Measurements. We use survival as a measurement here. Results. Patients who were able to withstand reduction in immunosuppression survived. Surgical resection or chemotherapy was successful in delaying progression of disease. Limitations. There was a relatively short follow-up for these slow-growing neoplasms. Conclusion. EBV-related SMNs have variable aggressiveness. While chemotherapy may slow disease progression, resection and improving the host immune status provide the best opportunity for primary tumor control.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders > immune system diseases
diseases & disorders > immune system diseases > immunological deficiency diseases
organism description > virus
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: 2008
Date Deposited: 26 Oct 2016 14:33
Last Modified: 26 Oct 2016 14:33
PMCID: PMC2590677
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33690

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