Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma

Eilber, F. C., Brennan, M. F., Eilber, F. R., Eckardt, J. J., Grobmyer, S. R., Riedel, E., Forscher, C., Maki, R. G., Singer, S. (July 2007) Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann Surg, 246 (1). pp. 105-13. ISSN 0003-4932 (Print)0003-4932 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/17592298
DOI: 10.1097/01.sla.0000262787.88639.2b

Abstract

PURPOSE: To determine if ifosfamide-based chemotherapy (IF) offers a survival benefit to adult patients with primary extremity synovial sarcoma. PATIENTS AND METHODS: Prospectively collected patient data from 2 institutions was used to identify all adult patients (>or=16 years) with >or=5 cm, deep, primary, extremity, synovial sarcoma that underwent surgical treatment of cure from 1990 to 2002. A total of 101 patients were identified and the median follow-up for survivors was 58 months. Clinical, pathologic, and treatment variables were analyzed for disease-specific survival (DSS), distant recurrence-free survival (DRFS), and local recurrence-free survival (LRFS). RESULTS: Sixty-eight (67%) patients were treated with IF and 33 (33%) patients received no chemotherapy (NoC) for the primary tumor. The characteristics of the IF-treated patients [median tumor size = 7.2 cm; monophasic n = 46 (68%)] were similar to NoC patients [median tumor size = 7 cm; monophasic n = 23 (70%)]. The 4-year DSS of the IF-treated patients was 88% compared with 67% for the NoC patients (P = 0.01). Smaller size (HR = 0.3 per 5-cm decrease, P < 0.0001) and treatment with IF (HR = 0.3 compared with NoC, P = 0.007) were independently associated with an improved DSS. Treatment with IF was independently associated with an improved DRFS (HR = 0.4, P = 0.03) but not associated with an improved LRFS (P = 0.39). CONCLUSION: Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients.

Item Type: Paper
Uncontrolled Keywords: Adolescent Adult Aged Antibiotics, Antineoplastic/therapeutic use Antineoplastic Agents, Alkylating/therapeutic use *Arm Disease-Free Survival Doxorubicin/*therapeutic use Female Follow-Up Studies Humans Ifosfamide/*therapeutic use *Leg Male Middle Aged Neoplasm Recurrence, Local/mortality Prospective Studies Sarcoma, Synovial/*drug therapy/*mortality Survival Rate/trends Treatment Outcome
Subjects: diseases & disorders > cancer > drugs and therapies > chemotherapy
diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > sarcoma
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: July 2007
Date Deposited: 26 Oct 2016 19:11
Last Modified: 26 Oct 2016 19:11
PMCID: PMC1899195
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33671

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