A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas

Anderson, S. E., Keohan, M. L., D'Adamo, D. R., Maki, R. G. (2006) A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Sarcoma, 2006. p. 15947. ISSN 1357-714X (Print)1357-714X (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/17496991
DOI: 10.1155/SRCM/2006/15947

Abstract

Introduction. The role of vinorelbine in specific soft tissue sarcoma subtypes is unclear. We present retrospective single institution experience with single-agent vinorelbine in subjects with metastatic soft tissue malignancies. Methods. Fifty-eight patients were treated with single agent intravenous vinorelbine between April 1997 and December 2004. Doxorubicin had been administered previously to 53 subjects (91%), and the median number of lines of previous chemotherapy was 3 (range 0-7). Results. Patients received a median 6 doses of vinorelbine (range 1-65). The overall response rate was 6% (3 patients: 1 angiosarcoma, 1 epithelioid sarcoma, and 1 embryonal rhabdomyosarcoma). Fourteen patients (26%) experienced a best result of stable disease. Median time to progression was 1.8 months (95% confidence intervals 1.5-2.1 months, Kaplan-Meier estimate). Eight patients experienced grade 3 or 4 toxicity, most commonly febrile neutropenia. Conclusion. Vinorelbine demonstrates limited activity in a heavily pretreated group of soft-tissue sarcoma patients. Prospective investigation may be considered for selected sarcoma subtypes.

Item Type: Paper
Subjects: diseases & disorders > cancer > drugs and therapies > chemotherapy
diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > sarcoma
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: 2006
Date Deposited: 26 Oct 2016 19:47
Last Modified: 26 Oct 2016 19:47
PMCID: PMC1698137
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33664

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