Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons

Drew, L. J., Kheirbek, M. A., Luna, V. M., Denny, C. A., Cloidt, M. A., Wu, M. V., Jain, S., Scharfman, H. E., Hen, R. (2016) Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons. Hippocampus, 26 (6). pp. 763-78. ISSN 1098-1063 (Electronic)1050-9631 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/26662922
DOI: 10.1002/hipo.22557

Abstract

Robust incorporation of new principal cells into pre-existing circuitry in the adult mammalian brain is unique to the hippocampal dentate gyrus (DG). We asked if adult-born granule cells (GCs) might act to regulate processing within the DG by modulating the substantially more abundant mature GCs. Optogenetic stimulation of a cohort of young adult-born GCs (0 to 7 weeks post-mitosis) revealed that these cells activate local GABAergic interneurons to evoke strong inhibitory input to mature GCs. Natural manipulation of neurogenesis by aging-to decrease it-and housing in an enriched environment-to increase it-strongly affected the levels of inhibition. We also demonstrated that elevating activity in adult-born GCs in awake behaving animals reduced the overall number of mature GCs activated by exploration. These data suggest that inhibitory modulation of mature GCs may be an important function of adult-born hippocampal neurons. (c) 2015 Wiley Periodicals, Inc.

Item Type: Paper
Uncontrolled Keywords: adult neurogenesis dentate gyrus granule cells hippocampus inhibition interneurons optogenetics
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neurogenesis
CSHL Authors:
Communities: CSHL labs > Tollkuhn lab
Depositing User: Matt Covey
Date Deposited: 07 Oct 2016 14:49
Last Modified: 07 Oct 2016 14:49
PMCID: PMC4867135
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33631

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