Central Control Circuit for Context-Dependent Micturition

Hou, Xun Helen, Hyun, Minsuk, Taranda, Julian, Huang, Kee Wui, Todd, Emmalee, Feng, Danielle, Atwater, Emily, Croney, Donyell, Zeidel, Mark Lawrence, Osten, Pavel, Sabatini, Bernardo Luis (September 2016) Central Control Circuit for Context-Dependent Micturition. Cell, 167 (1). pp. 73-86. ISSN 0092-8674

URL: https://www.ncbi.nlm.nih.gov/pubmed/27662084
DOI: 10.1016/j.cell.2016.08.073

Abstract

Summary Urine release (micturition) serves an essential physiological function as well as a critical role in social communication in many animals. Here, we show a combined effect of olfaction and social hierarchy on micturition patterns in adult male mice, confirming the existence of a micturition control center that integrates pro- and anti-micturition cues. Furthermore, we demonstrate that a cluster of neurons expressing corticotropin-releasing hormone (Crh) in the pontine micturition center (PMC) is electrophysiologically distinct from their Crh-negative neighbors and sends glutamatergic projections to the spinal cord. The activity of PMC Crh-expressing neurons correlates with and is sufficient to drive bladder contraction, and when silenced impairs micturition behavior. These neurons receive convergent input from widespread higher brain areas that are capable of carrying diverse pro- and anti-micturition signals, and whose activity modulates hierarchy-dependent micturition. Taken together, our results indicate that PMC Crh-expressing neurons are likely the integration center for context-dependent micturition behavior.

Item Type: Paper
Uncontrolled Keywords: micturition bladder Barrington's nucleus pons corticotropin-releasing hormone medial pre-optic area
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
CSHL Authors:
Communities: CSHL labs > Osten lab
Depositing User: Matt Covey
Date: 22 September 2016
Date Deposited: 23 Sep 2016 19:41
Last Modified: 28 Sep 2016 19:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/33544

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving