Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H)

Somerville, Tim D D., Vakoc, Christopher R (2016) Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H). Cancer Cell, 30 (1). pp. 9-10. ISSN 1535-6108

URL: http://www.ncbi.nlm.nih.gov/pubmed/27411582
DOI: 10.1016/j.ccell.2016.06.018

Abstract

In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3AR882H/NRASG12D acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA methylation
diseases & disorders > cancer > cancer types > leukemia
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > methyltransferase
CSHL Authors:
Communities: CSHL labs > Vakoc lab
Depositing User: Matt Covey
Date Deposited: 22 Jul 2016 19:07
Last Modified: 22 Jul 2016 19:07
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32975

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