Retrieving fear memories, as time goes by

Do Monte, F. H., Quirk, G. J., Li, B., Penzo, M. A. (August 2016) Retrieving fear memories, as time goes by. Mol Psychiatry, 21 (8). pp. 1027-1036. ISSN 1476-5578 (Electronic)1359-4184 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/27217148
DOI: 10.1038/mp.2016.78

Abstract

Research in fear conditioning has provided a comprehensive picture of the neuronal circuit underlying the formation of fear memories. In contrast, our understanding of the retrieval of fear memories is much more limited. This disparity may stem from the fact that fear memories are not rigid, but reorganize over time. To bring some clarity and raise awareness about the time-dependent dynamics of retrieval circuits, we review current evidence on the neuronal circuitry participating in fear memory retrieval at both early and late time points following auditory fear conditioning. We focus on the temporal recruitment of the paraventricular nucleus of the thalamus (PVT) for the retrieval and maintenance of fear memories. Finally, we speculate as to why retrieval circuits change with time, and consider the functional strategy of recruiting structures not previously considered as part of the retrieval circuit.

Item Type: Paper
Subjects: organism description > animal behavior > fear
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
CSHL Authors:
Communities: CSHL labs > Li lab
Depositing User: Matt Covey
Date: August 2016
Date Deposited: 31 May 2016 20:46
Last Modified: 26 Sep 2017 20:42
PMCID: PMC4956525
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32816

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