Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells

Ruiz-Reig, N., Andres, B., Huilgol, D., Grove, E. A., Tissir, F., Tole, S., Theil, T., Herrera, E., Fairen, A. (2017) Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells. Cereb Cortex, 27 (5). pp. 2841-2856. ISSN 1460-2199 (Electronic)1047-3211 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/27178193
DOI: 10.1093/cercor/bhw126

Abstract

A unique population of cells, called "lot cells," circumscribes the path of the lateral olfactory tract (LOT) in the rodent brain and acts to restrict its position at the lateral margin of the telencephalon. Lot cells were believed to originate in the dorsal pallium (DP). We show that Lhx2 null mice that lack a DP show a significant increase in the number of mGluR1/lot cells in the piriform cortex, indicating a non-DP origin of these cells. Since lot cells present common developmental features with Cajal-Retzius (CR) cells, we analyzed Wnt3a- and Dbx1-reporter mouse lines and found that mGluR1/lot cells are not generated in the cortical hem, ventral pallium, or septum, the best characterized sources of CR cells. Finally, we identified a novel origin for the lot cells by combining in utero electroporation assays and histochemical characterization. We show that mGluR1/lot cells are specifically generated in the lateral thalamic eminence and that they express mitral cell markers, although a minority of them express DeltaNp73 instead. We conclude that most mGluR1/lot cells are prospective mitral cells migrating to the accessory olfactory bulb (OB), whereas mGluR1+, DeltaNp73+ cells are CR cells that migrate through the LOT to the piriform cortex and the OB.

Item Type: Paper
Uncontrolled Keywords: Cajal-Retzius cells Tbr2 accessory olfactory bulb lateral thalamic eminence lot cells
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: Matt Covey
Date Deposited: 24 May 2016 20:37
Last Modified: 19 May 2017 20:00
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32813

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