T Antigen Is Bound to a Host Protein in Sv40-Transformed Cells

Lane, D. P., Crawford, L. V. (1979) T Antigen Is Bound to a Host Protein in Sv40-Transformed Cells. Nature, 278 (5701). pp. 261-263. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/218111
DOI: 10.1038/278261a0

Abstract

THE early region of the small DNA tumour virus, simian virus 40 (SV40), is known to code for at least two polypeptides, the t and T antigens (‘small t’ and ‘large T’). Both these polypeptides are expressed in cells transformed by the virus1–4, and the T antigen has been shown to be essential for both the initiation and maintenance of the transformed state5–9. We therefore need to know how this T protein interacts with components of the host cell in order to understand the mechanism of SV40-induced transformation. We report here that the T antigen in a line of SV40-transformed mouse cells forms an oligomeric complex with a specific cell coded protein.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells

organism description > virus > SV40
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 1979
Date Deposited: 16 May 2016 19:12
Last Modified: 16 May 2016 19:12
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32703

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