Viral Evasion of Cellular Defense-Mechanisms - Regulation of the Protein-Kinase Dai by Rna Effectors

Mathews, M. B. (August 1993) Viral Evasion of Cellular Defense-Mechanisms - Regulation of the Protein-Kinase Dai by Rna Effectors. Seminars in Virology, 4 (4). pp. 247-257. ISSN 1044-5773

URL: http://www.sciencedirect.com/science/article/pii/S...
DOI: 10.1006/smvy.1993.1021

Abstract

The protein kinase DAI (the double-stranded RNA activated inhibitor) plays a critical role in controlling translation in uninfected and infected cells. It is induced by interferon as part of the cellular antiviral defense mechanism. When activated, it leads to a blockade of polypeptide chain initiation, thereby interrupting viral propagation. Many viruses have developed means to neutralize the action of DAI: the sheer profusion of these countermeasures makes it clear that DAI is an important component of the host antiviral defense mechanism and a serious concern to the viruses. This chapter focusses on the mechanism of DAI activation and its inhibition by virus-encoded RNA antidotes.

Item Type: Paper
Uncontrolled Keywords: PROTEIN KINASE DAI EIF-2 DOUBLE-STRANDED RNA VIRAL RNA INTERFERON ANTIVIRAL DEFENSE MECHANISMS DOUBLE-STRANDED-RNA EPSTEIN-BARR-VIRUS INITIATION FACTOR-II ADENOVIRUS VA RNAI TAT GENE-PRODUCT MESSENGER-RNA INTERFERON ACTION INFECTED-CELLS TRANSLATIONAL CONTROL STRUCTURAL REQUIREMENTS
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > dsRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: August 1993
Date Deposited: 08 Apr 2016 15:14
Last Modified: 08 Apr 2016 15:14
URI: http://repository.cshl.edu/id/eprint/32601

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