A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

Sadowski, H. B., Shuai, K., Darnell, J. E., Gilman, M. Z. (September 1993) A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science, 261 (5129). pp. 1739-44. ISSN 0036-8075 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8397445
DOI: 10.1126/science.8397445

Abstract

Growth factors and cytokines act through cell surface receptors with different biochemical properties. Yet each type of receptor can elicit similar as well as distinct biological responses in target cells, suggesting that distinct classes of receptors activate common gene sets. Epidermal growth factor, interferon-gamma, and interleukin-6 all activated, through direct tyrosine phosphorylation, latent cytoplasmic transcription factors that recognized similar DNA elements. However, different ligands activated different patterns of factors with distinct DNA-binding specificities in the same and different cells. Thus, unrelated receptors may activate a common nuclear signal transduction pathway that, through differential use of latent cytoplasmic proteins, permits these receptors to regulate both common and unique sets of genes.

Item Type: Paper
Uncontrolled Keywords: Base Sequence Cell Nucleus/metabolism Cytokines/metabolism/ pharmacology DNA-Binding Proteins/ metabolism Epidermal Growth Factor/pharmacology Growth Substances/metabolism/pharmacology Humans Interferon Type II/pharmacology Interferon-Stimulated Gene Factor 3 Interleukin-6/pharmacology Molecular Sequence Data Phosphorylation Receptors, Cell Surface/ metabolism Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Signal Transduction Transcription Factors/ metabolism Tumor Cells, Cultured Tyrosine/metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > phosphorylation
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 24 September 1993
Date Deposited: 07 Apr 2016 19:43
Last Modified: 07 Apr 2016 19:43
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32597

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving