Cns Glial-Cells Express Neurotrophin Receptors Whose Levels Are Regulated by Ngf

Kumar, S., Pena, L. A., Devellis, J. (January 1993) Cns Glial-Cells Express Neurotrophin Receptors Whose Levels Are Regulated by Ngf. Molecular Brain Research, 17 (1-2). pp. 163-168. ISSN 0169-328X

URL: http://www.ncbi.nlm.nih.gov/pubmed/8381900
DOI: 10.1016/0169-328X(93)90086-5

Abstract

Normal CNS glial cells manufacture neurotrophin receptors and are competent to respond to NGF. Neurotrophins bind a common receptor (LNGFR) and ligand-specific, tyrosine kinase-containing subunits (TrkA, TrkB, or TrkC). Northern blots and transcription assays reveal complex transcriptional regulation of LNGFR in astrocytes; from undetectable basal levels, NGF dramatically induces LNGFR within 4-6 h. Oligodendrocytes' relatively high basal levels are unaffected by NGF. TrkA mRNA was undetectable, however, TrkB was present and upregulated by NGF in astrocytes but not oligodendrocytes. The results are consistent with receptor autoregulation by its ligand and suggest that NGF plays a role in normal glial functions.

Item Type: Paper
Uncontrolled Keywords: NERVE GROWTH FACTOR NERVE GROWTH FACTOR RECEPTOR TRK NEUROTROPHIN ASTROCYTE OLIGODENDROCYTE NERVE GROWTH-FACTOR MESSENGER-RNA GLIOMA-CELLS TRANSCRIPTIONAL REGULATION MOLECULAR-CLONING TYROSINE KINASE RAT ASTROCYTES FACTOR-ALPHA PROTEIN BRAIN
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > epidermal growth factor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: January 1993
Date Deposited: 13 Apr 2016 20:29
Last Modified: 13 Apr 2016 20:29
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32567

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving