Identification of Linotte, a New Gene Affecting Learning and Memory in Drosophila-Melanogaster

Dura, J. M., Preat, T., Tully, T. (1993) Identification of Linotte, a New Gene Affecting Learning and Memory in Drosophila-Melanogaster. Journal of Neurogenetics, 9 (1). pp. 1-14. ISSN 0167-7063

URL: http://www.ncbi.nlm.nih.gov/pubmed/18161591
DOI: 10.1080/01677060701693479

Abstract

We describe the identification of linotte, a new autosomal gene in Drosophila involved with learning and memory. The linotte' mutant was derived from a PlacW transposon mutagenesis and was screened for three-hour memory deficits after classical conditioning of an olfactory avoidance response. Sensory and motor systems (olfactory acuity and shock reactivity) required for the classical conditioning experiments were normal in mutant linotte1 flies-indicating that the mutation disrupts learning/memory specifically. A chromosomal deficiency of the 37D region, where the linotte1P insert was localized in situ, failed to complement linotte1's memory defect, and flies from two lines homozygous for independent PlacW excisions show normal memory-indicating that the P insertion is responsible for the mutant phenotype. Additional behavior-genetic data suggest that linotte gene is non-vital.

Item Type: Paper
Uncontrolled Keywords: CLASSICAL CONDITIONING OLFACTORY AVOIDANCE RESPONSE TRANSPOSON-TAGGING MUTAGENESIS CYCLIC-AMP PHOSPHODIESTERASE MUTANT RUTABAGA MUTATIONS CYCLASE GENOME LOCUS
Subjects: organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organism description > animal behavior > learning
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > linotte gene
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Matt Covey
Date: 1993
Date Deposited: 14 Apr 2016 16:56
Last Modified: 14 Apr 2016 16:56
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32552

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