A weight array method for splicing signal analysis

Zhang, M. Q., Marr, T. G. (October 1993) A weight array method for splicing signal analysis. Comput Appl Biosci, 9 (5). pp. 499-509. ISSN 0266-7061 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8293321

Abstract

A new method of sequence analysis, using a weight array method (WAM), which generalizes the traditional Staden weight matrix method (WMM), is proposed. With the help of a statistical mechanical model, the discriminant function is identified with the energy function describing macromolecular interactions. The method is applied to the study of 5'-splice signals in Schizosaccharomyces pombe pre-mRNA sequences. The results show that there may exist weak pairwise correlations within the signals and that our method can help to better discriminate these signals. Experiments are proposed to test the predictions of the theory.

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence Exons Humans Introns Models, Genetic Models, Statistical Molecular Sequence Data RNA Precursors/genetics RNA Splicing/ genetics RNA, Fungal/genetics Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Schizosaccharomyces/genetics Sequence Analysis, RNA/ methods/statistics & numerical data
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > exons
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > introns
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA splicing
CSHL Authors:
Communities: CSHL labs > Zhang lab
Depositing User: Matt Covey
Date: October 1993
Date Deposited: 21 Apr 2016 16:40
Last Modified: 21 Apr 2016 16:40
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32501

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving