Telomerase and telomere-length regulation: lessons from small eukaryotes to mammals

Greider, C. W. (June 1993) Telomerase and telomere-length regulation: lessons from small eukaryotes to mammals. Cold Spring Harb Symp Quant Biol, 58. pp. 719-23. ISSN 0091-7451 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7525147
DOI: 10.1101/SQB.1993.058.01.079

Abstract

Telomeres are molecular guardians of chromosome integrity. Broken chromosomes lacking telomeres often recombine to generate dicentrics and translocations that lead to chromosome rearrangements, amplification, and aneuploidy. The pioneering work of Müller and McClintock defined the telomere as the functional end of the chromosome, which is distinct from a random broken end (McClintock 1938; Müller 1938). As chromosome ends, telomeres are also faced with the problem of replicating the molecular 3′ end of a DNA molecule. The molecular mechanism of replicative DNA polymerases does not account for how molecular ends can be completely replicated (Watson 1972; Olovnikov 1973). This end-replication problem has been solved in nature in a variety of ways (for review, see Zakian 1989). The mechanism employed by most eukaryotic chromosomes is a baroque one: Sequence loss at the ends occurs but is compensated by de novo addition of telomeric sequences (for review, see Blackburn 1991).

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence DNA Nucleotidylexotransferase/genetics/ metabolism Eukaryotic Cells Humans Mammals Neoplasms/genetics/metabolism/ultrastructure RNA/genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Ribonucleoproteins/metabolism Saccharomyces cerevisiae/genetics/metabolism/ultrastructure Telomere/ metabolism/ultrastructure Zea mays/genetics/metabolism/ultrastructure
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote

organism description > animal > mammal
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres
CSHL Authors:
Communities: CSHL labs > Greider lab
Depositing User: Matt Covey
Date: June 1993
Date Deposited: 21 Apr 2016 16:16
Last Modified: 21 Apr 2016 16:16
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32498

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