Cooperative Subnetworks of Molecularly Similar Interneurons in Mouse Neocortex

Karnani, Mahesh M, Jackson, Jesse, Ayzenshtat, Inbal, Tucciarone, Jason, Manoocheri, Kasra, Snider, William G, Yuste, Rafael (2016) Cooperative Subnetworks of Molecularly Similar Interneurons in Mouse Neocortex. Neuron, 90 (1). pp. 86-100. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/27021171
DOI: 10.1016/j.neuron.2016.02.037

Abstract

Summary Simultaneous co-activation of neocortical neurons is likely critical for brain computations ranging from perception and motor control to memory and cognition. While co-activation of excitatory principal cells (PCs) during ongoing activity has been extensively studied, that of inhibitory interneurons (INs) has received little attention. Here, we show in vivo and in vitro that members of two non-overlapping neocortical IN populations, expressing somatostatin (SOM) or vasoactive intestinal peptide (VIP), are active as populations rather than individually. We demonstrate a variety of synergistic mechanisms, involving population-specific local excitation, GABAergic disinhibition and excitation through electrical coupling, which likely underlie IN population co-activity. Firing of a few SOM or VIP INs recruits additional members within the cell type via GABAergic and cholinergic mechanisms, thereby amplifying the output of the population as a whole. Our data suggest that IN populations work as cooperative units, thus generating an amplifying nonlinearity in their circuit output.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons

organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: Matt Covey
Date Deposited: 25 Mar 2016 15:48
Last Modified: 26 Aug 2016 21:14
PMCID: PMC4961215
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32460

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