Targeting Transcription Factors in Cancer

Bhagwat, A. S., Vakoc, C. R. (September 2015) Targeting Transcription Factors in Cancer. Trends Cancer, 1 (1). pp. 53-65. ISSN 2405-8033 (Print)

URL: http://www.ncbi.nlm.nih.gov//pubmed/26645049
DOI: 10.1016/j.trecan.2015.07.001

Abstract

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be highly effective in treating particular malignancies, as highlighted by the clinical efficacy of agents that target nuclear hormone receptors. In this review we discuss recent advances in our understanding of TFs as drug targets in oncology, with an emphasis on the emerging chemical approaches to modulate TF function. The remarkable diversity and potency of TFs as drivers of cell transformation justifies a continued pursuit of TFs as therapeutic targets for drug discovery.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Vakoc lab
Depositing User: Matt Covey
Date: 1 September 2015
Date Deposited: 01 Mar 2016 16:01
Last Modified: 01 Mar 2016 16:01
PMCID: PMC4669894
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32387

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving