Ancient trans-Acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response

Plavskin, Yevgeniy, Nagashima, Akitomo, Perroud, Pierre-François, Hasebe, Mitsuyasu, Quatrano, Ralph S, Atwal, Gurinder S, Timmermans, Marja C P. (February 2016) Ancient trans-Acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response. Developmental Cell, 36 (3). pp. 276-289. ISSN 1534-5807

URL: https://www.ncbi.nlm.nih.gov/pubmed/26859352
DOI: 10.1016/j.devcel.2016.01.010

Abstract

Summary Novel developmental programs often evolve via cooption of existing genetic networks. To understand this process, we explored cooption of the TAS3 tasiRNA pathway in the moss Physcomitrella patens. We find an ancestral function for this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response Factors. In moss, this results in stochastic patterning of the filamentous protonemal tissue. Through modeling and experimentation, we demonstrate that tasiRNA regulation confers sensitivity and robustness onto the auxin response. Increased auxin sensitivity parallels increased developmental sensitivity to nitrogen, a key environmental signal. We propose that the properties lent to the auxin response network, along with the ability to stochastically modulate development in response to environmental cues, have contributed to repeated cooption of the tasiRNA-ARF module during evolution. The signaling properties of a genetic network, and not just its developmental output, are thus critical to understanding evolution of multicellular forms.

Item Type: Paper
Uncontrolled Keywords: small RNA evolution gene regulatory network auxin Physcomitrella
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > auxin
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > siRNA
CSHL Authors:
Communities: CSHL labs > Atwal lab
CSHL labs > Timmermans lab
Watson School > Publications
Depositing User: Matt Covey
Date: 8 February 2016
Date Deposited: 09 Feb 2016 20:33
Last Modified: 27 Nov 2018 15:01
PMCID: PMC5444541
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32354

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