Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein

Dyson, N., Bernards, R., Friend, S. H., Gooding, L. R., Hassell, J. A., Major, E. O., Pipas, J. M., Vandyke, T., Harlow, E. (March 1990) Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol, 64 (3). pp. 1353-6. ISSN 0022-538X (Print)0022-538X (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/2154613

Abstract

Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Animals *Antigens, Polyomavirus Transforming/analysis/genetics Haplorhini Humans Molecular Sequence Data *Nuclear Proteins Papio *Phosphoproteins/analysis/metabolism Polyomavirus/genetics/*immunology Protein Binding Retinoblastoma Protein Sequence Homology, Nucleic Acid
Subjects: organism description > virus > adenovirus
diseases & disorders > cancer > cancer types > retinoblastoma
CSHL Authors:
Communities: CSHL labs > Stillman lab
Depositing User: Matt Covey
Date: March 1990
Date Deposited: 30 Mar 2016 16:54
Last Modified: 30 Mar 2016 16:54
PMCID: PMC249255
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32305

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