Transmission between pairs of hippocampal slice neurons: quantal levels, oscillations, and LTP

Malinow, R. (1991) Transmission between pairs of hippocampal slice neurons: quantal levels, oscillations, and LTP. Science, 252 (5006). pp. 722-4. ISSN 0036-8075 (Print)0036-8075 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/1850871
DOI: 10.1126/science.1850871

Abstract

Long-term potentiation (LTP) of synaptic transmission after coincident pre- and postsynaptic activity is considered a cellular model of changes underlying learning and memory. In intact tissue, LTP has been observed only between populations of neurons, making analysis of mechanisms difficult. Transmission between individual pre- and postsynaptic hippocampal cells was studied, suggesting quantal amplitude distributions with little variability in quantal size. LTP between such pairs is manifested by large, persistent, and synapse-specific potentiation with a shift in amplitude distribution that suggests presynaptic changes. Oscillations in amplitude of transmission, apparently of presynaptic origin, are common and can be triggered by LTP.

Item Type: Paper
Uncontrolled Keywords: Animals Electric Conductivity Electrophysiology Hippocampus/*cytology Kinetics Membrane Potentials Neurons/*physiology Rats Statistics as Topic Synapses/*physiology Synaptic Transmission/*physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
Investigative techniques and equipment > electrophysiology > brain slice
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date Deposited: 09 Dec 2015 20:34
Last Modified: 09 Dec 2015 20:34
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32165

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving