Early invasiveness characterizes metastatic carcinoid tumors in transgenic mice

Grant, S. G., Seidman, I., Hanahan, D., Bautch, V. L. (September 1991) Early invasiveness characterizes metastatic carcinoid tumors in transgenic mice. Cancer Res, 51 (18). pp. 4917-23. ISSN 0008-5472 (Print)0008-5472 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/1654206

Abstract

The conversion of a normal cell into a metastatic tumor is thought to occur in a stepwise progression of genetic changes that affect both growth control and interactions with the extracellular environment. The development of invasiveness allows tumor cells to escape from their primary site. We have investigated transgenic mice that develop both invasive intestinal neuroendocrine tumors and noninvasive tumors of the pancreatic beta-cells. Visual inspection and gene expression studies indicate that the beta-cell tumors rarely metastasize. In contrast, intestinal tumors that first appear in submucosal areas metastasize with high frequency to the lymph nodes and liver. No evidence of preneoplastic mucosal lesions was seen in the intestine, indicating that invasiveness is acquired early in the tumorigenic progression of these cells. Comparison of intestinal and pancreatic neuroendocrine tumors in transgenic mice suggests that an early requirement for invasiveness may contribute to metastatic potential.

Item Type: Paper
Uncontrolled Keywords: Animals Antigens, Viral, Tumor/genetics Carcinoid Tumor/genetics/pathology/*secondary Gene Expression Intestinal Neoplasms/*genetics/pathology Mice Mice, Transgenic/*genetics Neoplasm Invasiveness/*genetics/pathology Neoplasm Metastasis/genetics Pancreatic Neoplasms/*genetics/pathology Phenotype Promoter Regions, Genetic/genetics Simian virus 40/genetics/immunology Time Factors Tumor Cells, Cultured
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > metastasis
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: 15 September 1991
Date Deposited: 07 Jan 2016 21:35
Last Modified: 07 Jan 2016 21:35
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32070

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