The spliceosome, a potential Achilles heel of MYC-driven tumors

Anczukow, O., Krainer, A. R. (2015) The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Med, 7 (1). p. 107. ISSN 1756-994X (Electronic)1756-994X (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/26490253
DOI: 10.1186/s13073-015-0234-3

Abstract

Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > Myc
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > spliceosome complex
CSHL Authors:
Communities: CSHL labs > Krainer lab
Depositing User: Matt Covey
Date Deposited: 27 Oct 2015 18:56
Last Modified: 27 Oct 2015 18:56
PMCID: PMC4618744
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31956

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