Mechanisms of signal transduction by Ras

Bar-Sagi, D. (April 1992) Mechanisms of signal transduction by Ras. Semin Cell Biol, 3 (2). pp. 93-8. ISSN 1043-4682 (Print)1043-4682 (Linking)

Abstract

The role of Ras in the transduction of signals that control cell growth is undisputed. However, the identity of the Ras signalling pathway remains unknown. Evidence is mounting that Ras can receive signals from different cell surface receptors most likely via a common intermediate, GAP. A new insight into the possible function of Ras is provided by the recent findings that certain ligands can induce the coordinated redistribution of Ras and cell surface receptors. The next challenge is to identify the specific targets for the action of Ras.

Item Type:	Paper
Uncontrolled Keywords:	Animals Cell Division/physiology GTPase-Activating Proteins Gene Expression Regulation/physiology Genes, ras/*physiology Guanosine Diphosphate/metabolism/physiology Guanosine Triphosphate/metabolism/physiology Models, Biological Proteins/physiology Proto-Oncogene Proteins/*physiology Signal Transduction/*physiology ras GTPase-Activating Proteins
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction
CSHL Authors:	Bar-Sagi, Dafna
Communities:	CSHL labs
Depositing User:	Matt Covey
Date:	April 1992
Date Deposited:	18 Sep 2015 19:59
Last Modified:	18 Sep 2015 19:59
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/31867

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