Martin, K. A., Grant, S. G. N., Hockfield, S. (July 1992) The mas proto-oncogene is developmentally regulated in the rat central nervous system. Developmental Brain Research, 68 (1). pp. 75-82. ISSN 0165-3806
Abstract
The mas proto-oncogene encodes a protein with a predicted structure similar to members of the family of seven transmembrane domain spanning receptors. These receptors are thought to transduce extracellular signals to G-proteins. Angiotensin II and III have been reported to be the functional ligands for the mas oncogene-encoded receptor (Jackson et al., 1988). We show here using in situ hybridization histochemistry and RNase protection assays that mas mRNA is expressed in a subpopulation of neurons in both the adult and developing rat CNS. In the adult CNS, mas mRNA is most abundant in hippocampal pyramidal neurons and dentate granule cells; mas transcripts are also present at low levels in the cortex and thalamus. mas is first expressed in the developing rat CNS at postnatal day 1 (P1). Even at this early stage in CNS development the pattern of mas expression is similar to that seen in the adult. Although at P1 most neurons of the dentate gyros are not yet generated and cells of the hippocampal CA fields are undergoing migration and synaptogenesis (Bayer 1980; Altman and Bayer, 1990a, 1990b, 1990c), mas is specifically expressed in these cell populations. This extremely restricted pattern of expression suggests that mas may function in determining the morphology and connections of specific cell types in the hippocampus. This function may in part be carried out by the ability of mas to link external cues to intracellular processes.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | ONCOGENE HIPPOCAMPUS HYBRIDIZATION, INSITU RNASE PROTECTION ANGIOTENSIN MUSCARINIC ACETYLCHOLINE-RECEPTOR RENIN-ANGIOTENSIN SYSTEM SEROTONIN 1C RECEPTOR SUBSTANCE-P RECEPTOR C-FOS MOLECULAR CHARACTERIZATION FUNCTIONAL CDNA MULTIGENE FAMILY GRANULE CELLS EXPRESSION |
| Subjects: | organs, tissues, organelles, cell types and functions > organs types and functions > brain bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | July 1992 |
| Date Deposited: | 01 Oct 2015 14:58 |
| Last Modified: | 01 Oct 2015 14:58 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31787 |
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