Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

Menegas, W., Bergan, J. F., Ogawa, S. K., Isogai, Y., Umadevi Venkataraju, K., Osten, P., Uchida, N., Watabe-Uchida, M. (August 2015) Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. Elife, 4. ISSN 2050-084X (Electronic)2050-084X (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/26322384
DOI: 10.7554/eLife.10032

Abstract

Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, cortex, amygdala, etc.) in mice. We found that most populations of dopamine neurons receive a similar set of inputs rather than forming strong reciprocal connections with their target areas. A common feature among most populations of dopamine neurons was the existence of dense 'clusters' of inputs within the ventral striatum. However, we found that dopamine neurons projecting to the posterior striatum were outliers, receiving relatively few inputs from the ventral striatum and instead receiving more inputs from the globus pallidus, subthalamic nucleus, and zona incerta. These results lay a foundation for understanding the input/output structure of the midbrain dopamine circuit and demonstrate that dopamine neurons projecting to the posterior striatum constitute a unique class of dopamine neurons regulated by different inputs.

Item Type: Paper
Uncontrolled Keywords: anatomy dopamine input monosynaptic mouse neuroscience rabies virus striatum
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron

organs, tissues, organelles, cell types and functions > tissues types and functions > striatum
CSHL Authors:
Communities: CSHL labs > Osten lab
Depositing User: Matt Covey
Date: 31 August 2015
Date Deposited: 04 Sep 2015 19:01
Last Modified: 03 Nov 2017 18:45
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31737

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