MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment

Zhang, L., Sankaran, V. G., Lodish, H. F. (2012) MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia, 26 (11). pp. 2310-6. ISSN 1476-5551 (Electronic)0887-6924 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22617791
DOI: 10.1038/leu.2012.137

Abstract

MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been shown to be critical regulators of hematopoiesis and have important roles in the differentiation of specific lineages. Here, we summarize our current understanding of miRNAs involved in hematopoiesis with a focus on the role of miRNAs in regulating erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.

Item Type: Paper
Uncontrolled Keywords: Cell Differentiation/ physiology Cell Lineage Erythrocytes/ cytology Humans Megakaryocytes/ cytology MicroRNAs/genetics/ physiology
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation > erythropoiesis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
CSHL Authors:
Communities: CSHL labs > Zhang L. lab
Depositing User: Matt Covey
Date Deposited: 13 Jul 2015 19:59
Last Modified: 13 Jul 2015 19:59
PMCID: PMC3739046
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31619

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