Cortical Feedback Decorrelates Olfactory Bulb Output in Awake Mice

Otazu, Gonzalo H, Chae, Honggoo, Davis, Martin B, Albeanu, Dinu F (June 2015) Cortical Feedback Decorrelates Olfactory Bulb Output in Awake Mice. Neuron, 86 (6). pp. 1461-1477. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/26051422
DOI: 10.1016/j.neuron.2015.05.023

Abstract

Summary The olfactory bulb receives rich glutamatergic projections from the piriform cortex. However, the dynamics and importance of these feedback signals remain unknown. Here, we use multiphoton calcium imaging to monitor cortical feedback in the olfactory bulb of awake mice and further probe its impact on the bulb output. Responses of feedback boutons were sparse, odor specific, and often outlasted stimuli by several seconds. Odor presentation either enhanced or suppressed the activity of boutons. However, any given bouton responded with stereotypic polarity across multiple odors, preferring either enhancement or suppression. Feedback representations were locally diverse and differed in dynamics across bulb layers. Inactivation of piriform cortex increased odor responsiveness and pairwise similarity of mitral cells but had little impact on tufted cells. We propose that cortical feedback differentially impacts these two output channels of the bulb by specifically decorrelating mitral cell responses to enable odor separation.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Albeanu lab
Depositing User: Matt Covey
Date: 15 June 2015
Date Deposited: 10 Jun 2015 16:30
Last Modified: 01 Jul 2015 19:06
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31560

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