Stromal biology and therapy in pancreatic cancer: a changing paradigm

Neesse, A., Algul, H., Tuveson, D. A., Gress, T. M. (2015) Stromal biology and therapy in pancreatic cancer: a changing paradigm. Gut, 64 (9). pp. 1476-1484. ISSN 1468-3288 (Electronic)0017-5749 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/25994217
DOI: 10.1136/gutjnl-2015-309304

Abstract

Pancreatic ductal adenocarcinoma (PDA) exhibits one of the poorest prognosis of all solid tumours and poses an unsolved problem in cancer medicine. Despite the recent success of two combination chemotherapies for palliative patients, the modest survival benefits are often traded against significant side effects and a compromised quality of life. Although the molecular events underlying the initiation and progression of PDA have been intensively studied and are increasingly understood, the reasons for the poor therapeutic response are hardly apprehended. One leading hypothesis over the last few years has been that the pronounced tumour microenvironment in PDA not only promotes carcinogenesis and tumour progression but also mediates therapeutic resistance. To this end, targeting of various stromal components and pathways was considered a promising strategy to biochemically and biophysically enhance therapeutic response. However, none of the efforts have yet led to efficacious and approved therapies in patients. Additionally, recent data have shown that tumour-associated fibroblasts may restrain rather than promote tumour growth, reinforcing the need to critically revisit the complexity and complicity of the tumour-stroma with translational implications for future therapy and clinical trial design.

Item Type: Paper
Uncontrolled Keywords: Pancreatic disease Pancreatic fibrosis Pancreatic pathology Pancreatic tumours Pancreatitis
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date Deposited: 27 May 2015 20:16
Last Modified: 18 Sep 2015 16:14
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31536

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