Emerging structural insights into the function of ionotropic glutamate receptors

Karakas, Erkan, Regan, Michael C., Furukawa, Hiro (2015) Emerging structural insights into the function of ionotropic glutamate receptors. Trends in Biochemical Sciences, 40 (6). pp. 328-337. ISSN 0968-0004

URL: http://www.ncbi.nlm.nih.gov/pubmed/25941168
DOI: 10.1016/j.tibs.2015.04.002

Abstract

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory neurotransmission crucial for brain development and function, including learning and memory formation. Recently a wealth of structural studies on iGluRs including AMPA receptors (AMPARs), kainate receptors, and NMDA receptors (NMDARs) became available. These studies showed structures of non-NMDARs including AMPAR and kainate receptor in various functional states, thereby providing the first visual sense of how non-NMDAR iGluRs may function in the context of homotetramers. Furthermore, they provided the first view of heterotetrameric NMDAR ion channels, and this illuminated the similarities with and differences from non-NMDARs, thus raising a mechanistic distinction between the two groups of iGluRs. We review mechanistic insights into iGluR functions gained through structural studies of multiple groups.

Item Type: Paper
Uncontrolled Keywords: ionotropic glutamate receptors structural biology pharmacology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > ionotropic glutamate receptor
structural biology
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Furukawa lab
Stanley Institute for Cognitive Genomics
Depositing User: Matt Covey
Date Deposited: 07 May 2015 17:03
Last Modified: 06 Nov 2015 21:20
PMCID: PMC4464829
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31491

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