Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes

Demetrick, D. J., Zhang, H., Beach, D. H. (1994) Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. Cytogenet Cell Genet, 66 (1). pp. 72-4. ISSN 0301-0171 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8275715
DOI: 10.1159/000133669

Abstract

Cyclin dependent kinases (CDK's) are kinases that interact with cyclins and regulate cell division. Genomic clones encoding human CDK2, CDK4, and CDK5 were obtained and mapped to their respective chromosomal loci using fluorescence in situ hybridization on human lymphocyte metaphase spreads. Interestingly, CDK2 and CDK4 were located at the same position, 12q13, and CDK5 was mapped to 7q36. 12q13 has been shown to be associated with chromosome alterations such as amplifications and translocations in solid tumors. 7q36 does not appear to be a major site of chromosome alterations in tumors. As CDK2 and CDK4 appear to be important in regulating the human cell cycle, it is possible that the alterations of the 12q13 locus in tumors may involve changes in the regulation of CDK2 and CDK4 genes.

Item Type: Paper
Uncontrolled Keywords: CDC2-CDC28 Kinases Cell Cycle/ genetics Cell Division Chromosome Mapping Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 7 Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinases Cyclins/metabolism Humans In Situ Hybridization, Fluorescence/methods Lymphocytes/cytology/drug effects Metaphase Protein Kinases/ genetics Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
CSHL Authors:
Communities: CSHL labs > Beach lab
Depositing User: Matt Covey
Date: 1994
Date Deposited: 04 May 2015 14:17
Last Modified: 04 May 2015 14:17
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31475

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