Mammalian telomere dynamics: healing, fragmentation shortening and stabilization

Greider, C. W. (April 1994) Mammalian telomere dynamics: healing, fragmentation shortening and stabilization. Curr Opin Genet Dev, 4 (2). pp. 203-11. ISSN 0959-437X (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8032197
DOI: 10.1016/S0959-437X(05)80046-2

Abstract

Telomeres are essential for stable chromosome maintenance. The simple G-rich sequence motif d(TTAGGG)n is all that is required in cis for telomere function in mammalian cells, as in other eukaryotes. Using this fact, telomeres have been used to specifically fragment mammalian chromosomes to dissect their structure and function. Telomere length maintenance is altered in cancer cells. Trans-acting factors, such as telomerase and telomere-binding proteins, may determine telomere function in both normal and cancer cells. Current experiments are aimed at understanding the role of telomerase and telomere-binding proteins in cellular senescence and immortalization.

Item Type: Paper
Uncontrolled Keywords: Animals Base Sequence Chromosome Fragility DNA Nucleotidylexotransferase/metabolism Humans Molecular Sequence Data Neoplasms/enzymology/genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Telomere
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres
CSHL Authors:
Communities: CSHL labs > Greider lab
Depositing User: Matt Covey
Date: April 1994
Date Deposited: 03 Aug 2015 18:22
Last Modified: 03 Aug 2015 18:22
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31440

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