Potentiated Transmission and Prevention of Further Ltp by Increased Camkii Activity in Postsynaptic Hippocampal Slice Neurons

Pettit, D. L., Perlman, S., Malinow, R. (1994) Potentiated Transmission and Prevention of Further Ltp by Increased Camkii Activity in Postsynaptic Hippocampal Slice Neurons. Science, 266 (5192). pp. 1881-1885. ISSN 0036-8075

URL: http://www.ncbi.nlm.nih.gov/pubmed/7997883
DOI: 10.1126/science.7997883

Abstract

Calcium-calmodulin-dependent protein kinase II (CaMKII) is a necessary component of the cellular machinery underlying learning and memory. Here, a constitutively active form of this enzyme, CaMKII(1-290), was introduced into neurons of hippocampal slices with a recombinant vaccinia virus to test the hypothesis that increased postsynaptic activity of this enzyme is sufficient to produce long-term synaptic potentiation (LTP), a prominent cellular model of learning and memory. Postsynaptic expression of CaMKII(1-290) increased CaMKII activity, enhanced synaptic transmission, and prevented more potentiation by an LTP-inducing protocol. These results, together with previous studies, suggest that postsynaptic CaMKII activity is necessary and sufficient to generate LTP.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM POTENTIATION DEPENDENT PROTEIN-KINASE DENSITY PROTEIN FASCIA DENTATA SYNAPTIC ENHANCEMENT SYNTHETIC MACHINERY NMDA RECEPTORS CA1 NEURONS CALMODULIN ACTIVATION
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
Investigative techniques and equipment > electrophysiology > brain slice
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date Deposited: 30 Jun 2015 19:08
Last Modified: 30 Jun 2015 19:08
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31435

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