Bourtchuladze, R., Frenguelli, B., Blendy, J., Cioffi, D., Schutz, G., Silva, A. J. (October 1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell, 79 (1). pp. 59-68. ISSN 0092-8674 (Print)
Abstract
The cAMP-responsive element-binding protein (CREB) has been implicated in the activation of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia. Our studies with fear conditioning and with the water maze show that mice with a targeted disruption of the alpha and delta isoforms of CREB are profoundly deficient in long-term memory. In contrast, short-term memory, lasting between 30 and 60 min, is normal. Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation. However, paired-pulse facilitation and posttetanic potentiation are normal. These results implicate CREB-dependent transcription in mammalian long-term memory.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Association Learning Conditioning (Psychology) Cyclic AMP Response Element-Binding Protein/genetics/ physiology Electrophysiology Female Hippocampus/physiology Long-Term Potentiation Male Memory/ physiology Mice Mice, Neurologic Mutants Mutation/ physiology Research Support, Non-U.S. Gov't |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > Cyclic AMP organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab |
| Depositing User: | Matt Covey |
| Date: | 7 October 1994 |
| Date Deposited: | 27 Aug 2015 15:25 |
| Last Modified: | 27 Aug 2015 15:25 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31415 |
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