Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

Yin, J. C., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., Tully, T. (October 1994) Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell, 79 (1). pp. 49-58. ISSN 0092-8674 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7923376
DOI: 10.1016/0092-8674(94)90399-9

Abstract

Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Animals Animals, Genetically Modified Conditioning, Classical Cyclic AMP Response Element-Binding Protein/ genetics/physiology Drosophila/ genetics/physiology Gene Expression Genes, Dominant/physiology Genes, Insect/ physiology Heat Memory/ physiology Molecular Sequence Data RNA, Messenger/biosynthesis Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Matt Covey
Date: 7 October 1994
Date Deposited: 27 Aug 2015 15:08
Last Modified: 27 Aug 2015 15:08
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31414

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