Mice Deficient for the Myelin-Associated Glycoprotein Show Subtle Abnormalities in Myelin

Montag, D., Giese, K. P., Bartsch, U., Martini, R., Lang, Y., Bluthmann, H., Karthigasan, J., Kirschner, D. A., Wintergerst, E. S., Nave, K. A., Zielasek, J., Toyka, K. V., Lipp, H. P., Schachner, M. (July 1994) Mice Deficient for the Myelin-Associated Glycoprotein Show Subtle Abnormalities in Myelin. Neuron, 13 (1). pp. 229-246. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/7519026
DOI: 10.1016/0896-6273(94)90472-3

Abstract

Using homologous recombination in embryonic stem cells, we have generated mice with a null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition molecule implicated in myelin formation. MAG-deficient mice appeared normal in motor coordination and spatial learning tasks. Normal myelin structure and nerve conduction in the PNS, with N-CAM overexpression at sites normally expressing MAG, suggested compensatory mechanisms. In the CNS, the onset of myelination was delayed, and subtle morphological abnormalities were detected in that the content of oligodendrocyte cytoplasm at the inner aspect of most myelin sheaths was reduced and that some axons were surrounded by two or more myelin sheaths. These observations suggest that MAG participates in the formation of the periaxonal cytoplasmic collar of oligodendrocytes and in the recognition between oligodendrocyte processes and axons.

Item Type: Paper
Uncontrolled Keywords: PERIPHERAL NERVOUS-SYSTEM CELL-ADHESION MOLECULES MOUSE SCIATIC-NERVE IMMUNOELECTRON MICROSCOPIC LOCALIZATION EXPERIMENTAL ALLERGIC NEURITIS ADULT-MOUSE BASIC-PROTEIN N-CAM L2/HNK-1 CARBOHYDRATE NUCLEOTIDE-SEQUENCE
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > myelin basic protein
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > myelinating cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > myelinating cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > myelinating cells
CSHL Authors:
Depositing User: Matt Covey
Date: July 1994
Date Deposited: 27 Aug 2015 20:54
Last Modified: 27 Aug 2015 20:54
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31397

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