T cell exclusion, immune privilege, and the tumor microenvironment

Joyce, J. A., Fearon, D. T. (April 2015) T cell exclusion, immune privilege, and the tumor microenvironment. Science, 348 (6230). pp. 74-80. ISSN 0036-8075

URL: http://www.ncbi.nlm.nih.gov/pubmed/25838376
DOI: 10.1126/science.aaa6204

Abstract

Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific T cells be generated, but also that these T cells physically contact cancer cells. The coexistence in some patients of cancer cells and T cells that recognize them indicates that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from immune attack. Here, we review the evidence that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells. Overcoming this T cell checkpoint may thus enable optimal immunotherapy.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > immune cell

diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:
Communities: CSHL labs > Fearon lab
Depositing User: Matt Covey
Date: 3 April 2015
Date Deposited: 17 Apr 2015 15:01
Last Modified: 17 Apr 2015 15:01
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31321

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