Emergent behavior of growing knowledge about molecular interactions

Cokol, M., Iossifov, I., Weinreb, C., Rzhetsky, A. (2005) Emergent behavior of growing knowledge about molecular interactions. Nat Biotechnol, 23 (10). pp. 1243-7. ISSN 1087-0156 (Print)1087-0156 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/16211067
DOI: 10.1038/nbt1005-1243

Abstract

In the time of Isaac Newton (1643–1727), a prominent scientist could follow advances in multiple fields of knowledge—as far apart from each other as mathematics, astronomy, physics, history and theology. It took a talent of Newton's caliber, of course, to contribute to several of them during one lifetime. Today, with thousands of biomedical journals published in English alone, even Sir Isaac would not have the luxury of systematically following all that happens in biology, let alone in multiple research fields. Currently, millions of active biomedical researchers are scattered around the globe, most focusing on a small fragment of the enormous biological universe. Consequently, knowledge acquisition and validation by scientific communities is bound to have large-scale properties that are normally hidden from individual scientists. These large-scale properties would reveal themselves only at the level of a meta-analysis of large volumes of data produced by numerous scientists. The practical importance of such meta-analyses—besides satisfying academic curiosity—lies in their potential for indicating hidden opportunities lurking in the currently accessible knowledge.

Item Type: Paper
Uncontrolled Keywords: Artificial Intelligence Databases, Bibliographic Information Storage and Retrieval/ methods Molecular Biology/methods Natural Language Processing Periodicals as Topic Protein Interaction Mapping/ methods Proteome/ metabolism Signal Transduction/ physiology Vocabulary, Controlled
Subjects: bioinformatics
bioinformatics > genomics and proteomics > databases
CSHL Authors:
Communities: CSHL labs > Iossifov lab
Depositing User: Matt Covey
Date Deposited: 01 Apr 2015 19:08
Last Modified: 01 Apr 2015 19:08
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31300

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