Selective corticostriatal plasticity during acquisition of an auditory discrimination task

Xiong, Q., Znamenskiy, P., Zador, A. M. (May 2015) Selective corticostriatal plasticity during acquisition of an auditory discrimination task. Nature, 521 (7552). pp. 348-351. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/25731173
DOI: 10.1038/nature14225

Abstract

Perceptual decisions are based on the activity of sensory cortical neurons, but how organisms learn to transform this activity into appropriate actions remains unknown. Projections from the auditory cortex to the auditory striatum carry information that drives decisions in an auditory frequency discrimination task. To assess the role of these projections in learning, we developed a channelrhodopsin-2-based assay to probe selectively for synaptic plasticity associated with corticostriatal neurons representing different frequencies. Here we report that learning this auditory discrimination preferentially potentiates corticostriatal synapses from neurons representing either high or low frequencies, depending on reward contingencies. We observe frequency-dependent corticostriatal potentiation in vivo over the course of training, and in vitro in striatal brain slices. Our findings suggest a model in which the corticostriatal synapses made by neurons tuned to different features of the sound are selectively potentiated to enable the learned transformation of sound into action.

Item Type: Paper
Subjects: organism description > animal behavior > auditory
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > corticostriatal neurons
CSHL Authors:
Communities: CSHL labs > Zador lab
Watson School > Publications
Depositing User: Matt Covey
Date: 21 May 2015
Date Deposited: 13 Mar 2015 19:33
Last Modified: 10 Jun 2015 20:29
PMCID: PMC4454418
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31269

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