A subcortical inhibitory signal for behavioral arrest in the thalamus

Giber, K., Diana, M. A., V, M. Plattner, Dugue, G. P., Bokor, H., Rousseau, C. V., Magloczky, Z., Havas, L., Hangya, B., Wildner, H., Zeilhofer, H. U., Dieudonne, S., Acsady, L. (February 2015) A subcortical inhibitory signal for behavioral arrest in the thalamus. Nature Neuroscience, 18. pp. 562-568. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/25706472
DOI: 10.1038/nn.3951

Abstract

Organization of behavior requires rapid coordination of brainstem and forebrain activity. The exact mechanisms of effective communication between these regions are presently unclear. The intralaminar thalamic nuclei (IL) probably serves as a central hub in this circuit by connecting the critical brainstem and forebrain areas. We found that GABAergic and glycinergic fibers ascending from the pontine reticular formation (PRF) of the brainstem evoked fast and reliable inhibition in the IL via large, multisynaptic terminals. This inhibition was fine-tuned through heterogeneous GABAergic and glycinergic receptor ratios expressed at individual synapses. Optogenetic activation of PRF axons in the IL of freely moving mice led to behavioral arrest and transient interruption of awake cortical activity. An afferent system with comparable morphological features was also found in the human IL. These data reveal an evolutionarily conserved ascending system that gates forebrain activity through fast and powerful synaptic inhibition of the IL.

Item Type: Paper
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits

organs, tissues, organelles, cell types and functions > tissues types and functions > thalamus
CSHL Authors:
Communities: CSHL labs > Kepecs lab
Depositing User: Matt Covey
Date: 23 February 2015
Date Deposited: 27 Feb 2015 16:52
Last Modified: 17 Apr 2015 16:04
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31250

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