Cis-regulatory elements and human evolution

Siepel, A., Arbiza, L. (2014) Cis-regulatory elements and human evolution. Curr Opin Genet Dev, 29c. pp. 81-89. ISSN 0959-437x

URL: http://www.ncbi.nlm.nih.gov/pubmed/25218861
DOI: 10.1016/j.gde.2014.08.011

Abstract

Modification of gene regulation has long been considered an important force in human evolution, particularly through changes to cis-regulatory elements (CREs) that function in transcriptional regulation. For decades, however, the study of cis-regulatory evolution was severely limited by the available data. New data sets describing the locations of CREs and genetic variation within and between species have now made it possible to study CRE evolution much more directly on a genome-wide scale. Here, we review recent research on the evolution of CREs in humans based on large-scale genomic data sets. We consider inferences based on primate divergence, human polymorphism, and combinations of divergence and polymorphism. We then consider 'new frontiers' in this field stemming from recent research on transcriptional regulation.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > cis-regulatory elements
evolution
CSHL Authors:
Communities: CSHL labs > Siepel lab
Depositing User: Matt Covey
Date Deposited: 13 Jan 2015 20:51
Last Modified: 13 Jan 2015 20:51
PMCID: PMC4258466
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31096

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