Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing

Gottipati, S., Arbiza, L., Siepel, A., Clark, A. G., Keinan, A. (2011) Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing. Nat Genet, 43 (8). pp. 741-3. ISSN 1061-4036

URL: http://www.ncbi.nlm.nih.gov/pubmed/21775991
DOI: 10.1038/ng.877

Abstract

The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.

Item Type: Paper
Uncontrolled Keywords: Chromosome Mapping Chromosomes, Human, X/*genetics Demography Female Genes, X-Linked/*genetics Genetic Variation/*genetics *Genetics, Population *Genome, Human Humans Selection, Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
Investigative techniques and equipment > assays > whole genome sequencing
CSHL Authors:
Communities: CSHL labs > Siepel lab
Depositing User: Matt Covey
Date Deposited: 15 Jan 2015 17:03
Last Modified: 15 Jan 2015 17:03
PMCID: PMC3145052
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31062

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