Differential regulation of synaptic and extra-synaptic NMDA receptors

Li, B., Chen, N., Luo, T., Otsu, Y., Murphy, T. H., Raymond, L. A. (September 2002) Differential regulation of synaptic and extra-synaptic NMDA receptors. Nature Neuroscience, 5 (9). pp. 833-4. ISSN 1097-6256 (Print)1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/12195433
DOI: 10.1038/nn912

Abstract

A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown--the decline of peak current with repeated, sustained agonist application. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.

Item Type: Paper
Uncontrolled Keywords: Animals Calcium/metabolism Calcium Signaling/drug effects/physiology Cell Membrane/drug effects/metabolism Cells, Cultured Endocytosis/drug effects/physiology Excitatory Amino Acid Antagonists/pharmacology Excitatory Postsynaptic Potentials/drug effects/*physiology Hippocampus/cytology/drug effects/*metabolism N-Methylaspartate/pharmacology Phosphoric Monoester Hydrolases/metabolism Piperidines/pharmacology Protein Transport/drug effects/physiology Protein-Tyrosine Kinases/antagonists & inhibitors/metabolism Pyramidal Cells/cytology/drug effects/*metabolism Rats Receptors, N-Methyl-D-Aspartate/drug effects/*metabolism Synapses/drug effects/*metabolism Synaptic Transmission/drug effects/*physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic plasticity
CSHL Authors:
Depositing User: Matt Covey
Date: September 2002
Date Deposited: 12 Dec 2014 16:21
Last Modified: 12 Dec 2014 16:21
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30966

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