The RAS and YAP1 dance, who is leading?

Corbo, V., Ponz-Sarvise, M., Tuveson, D. A. (September 2014) The RAS and YAP1 dance, who is leading? EMBO journal, 33 (21). pp. 3437-2438. ISSN 0261-4189

URL: http://www.ncbi.nlm.nih.gov/pubmed/25257311
DOI: 10.15252/embj.201490014

Abstract

The Hippo‐signaling effector YAP1 was recently found to compensate for oncogenic RAS in certain neoplasms, suggesting so far unanticipated molecular interplays between these major signaling routes. A new study in this issue of The EMBO Journal details KRAS‐dependent control of YAP1 stability as well as positive feedback regulation via the RAS/YAP1/EGFR‐ligand axis as novel molecular mechanisms that could become exploitable for therapeutic strategies.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > epidermal growth factor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date: 25 September 2014
Date Deposited: 05 Dec 2014 21:15
Last Modified: 20 Feb 2015 16:50
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30963

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