Extracellular modulators of Wnt signalling

Malinauskas, Tomas, Jones, E. Yvonne (2014) Extracellular modulators of Wnt signalling. Current Opinion in Structural Biology, 29. pp. 77-84. ISSN 0959-440X

URL: http://www.ncbi.nlm.nih.gov/pubmed/25460271
DOI: 10.1016/j.sbi.2014.10.003

Abstract

Wnt morphogens are secreted signalling proteins that play leading roles in embryogenesis and tissue homeostasis throughout life. Wnt signalling is controlled by multiple mechanisms, including posttranslational modification of Wnts, antagonist binding (to Wnts or their receptors), and regulation of the availability of Wnt receptors. Recent crystallographic, structure-guided biophysical and cell-based studies have advanced our understanding of how Wnt signalling is regulated at the cell surface. Structures include Wnt in complex with the cysteine-rich domain (CRD) of Frizzled, extracellular fragments of Wnt co-receptor LRP6, LRP6-binding antagonists Dickkopf and Sclerostin, antagonists 5T4/WAIF1 and Wnt inhibitory factor 1 (WIF-1), as well as Frizzled–ubiquitin ligases ZNRF3/RNF43 (in isolation and in complexes with Wnt signalling promoters R-spondins and LGR5). We review recent discoveries and remaining questions.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Wnt
CSHL Authors:
Communities: CSHL labs > Furukawa lab
Depositing User: Matt Covey
Date Deposited: 24 Oct 2014 16:06
Last Modified: 08 Sep 2015 14:21
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30876

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