Brd4 is on the move during inflammation

Xu, Y., Vakoc, C. R. (November 2014) Brd4 is on the move during inflammation. Trends in Cell Biology, 24 (11). pp. 615-616. ISSN 0962-8924

URL: http://www.ncbi.nlm.nih.gov/pubmed/25288306
DOI: 10.1016/j.tcb.2014.09.005

Abstract

Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.

Item Type: Paper
Uncontrolled Keywords: Brd4 p65 NF-kB enhancer super-enhancer inflammation JQ1 BET bromodomain
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > BET bromodomain coactivator protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > BET bromodomain coactivator protein > Brd4
diseases & disorders > inflammation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NF-kappaB
CSHL Authors:
Communities: CSHL labs > Vakoc lab
Depositing User: Matt Covey
Date: November 2014
Date Deposited: 09 Oct 2014 18:50
Last Modified: 24 Apr 2015 18:43
PMCID: PMC4252248
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30831

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