Toward a Genetic Dissection of Cortical Circuits in the Mouse

Huang, Z. J. (2014) Toward a Genetic Dissection of Cortical Circuits in the Mouse. Neuron, 83 (6). pp. 1284-1302. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/25233312
DOI: 10.1016/j.neuron.2014.08.041

Abstract

The mammalian neocortex gives rise to a wide range of mental activities and consists of a constellation of interconnected areas that are built from a set of basic circuit templates. Major obstacles to understanding cortical architecture include the diversity of cell types, their highly recurrent local and global connectivity, dynamic circuit operations, and a convoluted developmental assembly process rooted in the genome. With our increasing knowledge of gene expression and developmental genetic principles, it is now feasible to launch a program of genetic dissection of cortical circuits through systematic targeting of cell types and fate mapping of neural progenitors. Strategic design of even a modest number of mouse driver lines will facilitate efforts to compile a cell type parts list, build a Cortical Cell Atlas, establish experimental access to modern tools, integrate studies across levels, and provide coordinates for tracing developmental trajectory from circuit assembly to functional operation.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits

Investigative techniques and equipment > Whole Brain Circuit Mapping
CSHL Authors:
Communities: CSHL labs > Huang lab
Depositing User: Matt Covey
Date Deposited: 25 Sep 2014 14:21
Last Modified: 25 Sep 2014 14:21
PMCID: PMC4169123
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30818

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