A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC

Beck, S., Hanson, I., Kelly, A., Pappin, D. J., Trowsdale, J. (1992) A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. DNA Seq, 2 (4). pp. 203-10. ISSN 1042-5179 (Print)1026-7913 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/1352711

Abstract

The RING3 gene maps in the class II region of the human major histocompatibility complex, at a CpG island distal of the HLA-DNA gene. RING3 cDNAs were obtained from a T cell cDNA library and the longest (4 kb) was sequenced. The sequence contained an open reading frame encoding a protein of 754 amino acids. A screen of protein databases revealed striking homology between the RING3 protein and the Drosophila female sterile homeotic gene (fsh) which is implicated in the establishment of segments in the early embryo. Partial sequence homology was also observed with some other proteins involved in cell cycle control (CCG1), cell division (ftsA) and regulation of cell growth (gamma interferons). This highly conserved gene may play an important role in human development. In addition, its location in the MHC class II region may be related to some HLA-associated diseases.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Animals Base Sequence Chromosome Mapping DNA/genetics Drosophila/ genetics Female Genes, Homeobox Genes, MHC Class II Humans Infertility, Female/genetics Interferon-gamma/genetics Molecular Sequence Data Sequence Homology, Nucleic Acid Transcription, Genetic
Subjects: organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > homeobox genes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > major histocompatibility complex
CSHL Authors:
Communities: CSHL labs > Pappin lab
Depositing User: Matt Covey
Date: 1992
Date Deposited: 18 Sep 2014 14:48
Last Modified: 18 Sep 2014 14:48
URI: http://repository.cshl.edu/id/eprint/30757

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