CDC25 phosphatases as potential human oncogenes

Galaktionov, K., Lee, A. K., Eckstein, J., Draetta, G., Meckler, J., Loda, M., Beach, D. (1995) CDC25 phosphatases as potential human oncogenes. Science, 269 (5230). pp. 1575-7. ISSN 0036-8075 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7667636

Abstract

Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RASG12V or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.

Item Type: Paper
Uncontrolled Keywords: Animals Breast Neoplasms/genetics Cell Cycle Proteins/ genetics Cell Division Cell Transformation, Neoplastic Cells, Cultured Gene Expression Genes, Retinoblastoma Genes, p53 Genes, ras Humans In Situ Hybridization Mice Mice, Inbred BALB C Mice, Nude Multigene Family Neoplasm Transplantation Oncogenes Phosphoprotein Phosphatase/ genetics Prognosis Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Transfection Tumor Cells, Cultured cdc25 Phosphatase
Subjects: diseases & disorders > neoplasms
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organism description > animal > mammal > primates > hominids > human
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Beach lab
Depositing User: Jessica Koos
Date Deposited: 14 Aug 2014 14:45
Last Modified: 14 Aug 2014 14:45
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30593

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