Dissection of memory formation: from behavioral pharmacology to molecular genetics

DeZazzo, J., Tully, T. (May 1995) Dissection of memory formation: from behavioral pharmacology to molecular genetics. Trends Neurosci, 18 (5). pp. 212-8. ISSN 0166-2236 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7610491
DOI: 10.1016/0166-2236(95)93905-D

Abstract

Behavioral pharmacology has suggested an intricate, multiphasic pathway of memory consolidation. An integrated molecular pharmacological approach in Drosophila has lent support to this theory recently by dissecting consolidated memory into two genetically distinct components: a cycloheximide-insensitive, anesthesia-resistant memory and a cycloheximide-sensitive long-term memory. In addition, experiments using inducible dominant-negative transgenes in Drosophila or gene knockouts in mice demonstrate a role for cAMP-responsive transcription factors in formation of long-term memory. These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation.

Item Type: Paper
Uncontrolled Keywords: Animals Cyclic AMP/pharmacology Cycloheximide/pharmacology Drosophila Genes Memory/ physiology Molecular Biology Neural Pathways/physiology Neuropharmacology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Time Factors Transcription Factors
Subjects: organism description > animal > insect > Drosophila
organism description > animal
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Jessica Koos
Date: May 1995
Date Deposited: 12 Aug 2014 13:56
Last Modified: 12 Aug 2014 13:56
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30588

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